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section Studies
Microangiopathy IN Diabetes(MIND) : 2024-01, 2027-06
Capillary dysfunction in Sepsis(CapriS) : 2024-01, 2028-06
SCAPIS2Spectrum - Microcirculation substudy : 2024-03, 2029-01
section Conferences
European Society on Microcirculation :milestone 2025-05, 2025-06
ISICEM :milestone 2026-03, 2026-04
European Society on Microcirculation :milestone 2027-04, 2027-05
section Journal clubs
IMA-Journal Clubs : 2024-08, 2029-05
section Milestones
Start date :milestone, 2024-08, 2024-08
Half-Time Control :milestone, 2026-08, 2026-08
Dissertation Defense :milestone, crit, 2029-05, 2029-05
Individual study plan
Bedside assessment of Microvascular Dysfunction Method evaluation in clinical studies
Disposition
- Introduction and Background: Introduction to the topic, research objectives
- Research plan and Methodology: Study designs, methods and analysis
- Timeline and Milestones: Project timeline with key milestones
- Education: Courses, journal clubs, conferences
- Degree outcomes
- Resources and Support: Overview of resources and support
Introduction and Background
Relevance
Introduction and Background
Relevance
Key Areas: Cardiovascular disease, diabetes, heart failure, sepsis
Clinical Implications
Early Detection and Prevention: Monitoring microvascular function helps identify patients at high risk, enabling early intervention and preventive measures.
Disease Progression and Treatment Monitoring: Microvascular assessment provides a window into disease activity, aiding in the evaluation of treatment effectiveness.
Goal-Directed Therapy: Insights into microvascular health support goal-directed therapies, optimizing treatment plans tailored to individual needs.
Introduction and Background
Problem
Current methods
Capillary refill time
Subjectivity, variability, sens/spec, non-quantifiable*
Coronary angiography
Invasive, cumbersome, resource intensive, organ specific
Stress Cardiac MRT
Cumbersome, resource intensive, organ specific
Biomarkers
Analysis time, interpretation, resource intensive
Introduction and Background
Problem
Future methods - what is needed?
Quantitative
Precision and comparison
Non-invasive
Risk and discomfort
Low variability and High sensitivity
Consistency and precision
Rapid and ease of use
Clinical convenience
Organ-agnostic
Systemic dysfunction
Cost-effective
Iterative usage and goal-directed
Research Plan and Methodology
- The CapriS Study, Capillary Dysfunction in Sepsis
- Patients with severe sepsis or septic shock
- Rapid microvascular decompensation
- Patients with severe sepsis or septic shock
- The MIND Study, Microangiopathy in Diabetes
- Patients with type 1 diabetes, with and without clinical microangiopathy
- Chronic microvascular deterioration
- Patients with type 1 diabetes, with and without clinical microangiopathy
- SCAPIS2Spectrum, Microcirculation Substudy
- Patients with high risk of cardiac microangiopathy
- Microangiopathy in different populations
- Microangiopathy in different populations
- Patients with high risk of cardiac microangiopathy
Research Plan and Methodology
CapriS, Capillary Dysfunction in Sepsis
60 patients, >18 yrs with confirmed/suspected infection at ICU/IMCU <12hrs and SBP <90mmHg despite 10 mL/kg cristalloid. Laser speckle contrast imaging, with iontophoresis. Biomarkers. Echocardiography at set intervals.
30 healthy controls.
Primary outcome: peak capillary blood cell velocity (pCVB, mm/s)
Secondary outcomes: Severity of condition, macrocirculatory parameters, biomarkers.
Research Plan and Methodology
MIND, Microangiopathy in Diabetes
- Patient
- Intervention
- Comparison
- Outcome
Research Plan and Methodology
SCAPIS2Spectrum, Microcirculation Substudy
- Patient
- Intervention
- Comparison
- Outcome
Timeline and Milestones
Timeline and Milestones
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dateFormat YYYY-MM
section Mandatory courses
Introduction to Doctoral Education at KI : 2024-10, 2024-12
Basic Laboratory Safety : 2024-12, 2025-01
Medical Research Ethics : 2025-01, 2025-02
Introductory course in clinical studies : 2025-02, 2025-03
Basic Course in Medical Statistics : 2025-03, 2025-04
Present your Research! : 2025-10, 2025-11
Quality Assurance of Clinical Research : 2025-10, 2025-11
section Project specific courses
Statistical Methods with R : 2024-09, 2024-12
Programing in Python : 2024-08, 2024-11
Endothelial Cell Function[...] : 2026-02, 2026-03
Intermediate Medical Statistics : 2026-03, 2026-04
Cellular Signalling : 2026-04, 2026-05
section Milestones
Start date :milestone, 2024-08, 2024-08
Half-Time Control :milestone, 2026-08, 2026-08
Dissertation Defense :milestone, crit, 2029-05, 2029-05
Education
- All courses listed here, 20 hp wow
Education
Journal clubs and conferences
- wow so many journal clubs
Degree outcomes
- So many outcomes!
Challanges and Risk Management
- Large Scale Studies
- Participant Scheduling
- Automatic scheduling system
- Data Collection
- Partially automatic data collection and integrity system
- Participant Scheduling
- Data Analysis Phase
- Well-defined analytic aims
- Specific courses
Resources and Support
- Supervisor: Sara Tehrani, MD, PhD, MICU specialist
- Co-Supervisor: Maria Cronhjort, MD, PhD, anesthesiologist and ICU specialist
Discussion and Feedback